Testosterone levels among men with spinal cord injury: relationship between time since injury and laboratory values

The mechanisms underlying the beneficial effects of exogenous testosterone on spermatogenesis of mice with SCI, remain to bedetermined. Futhermore, the effect of exogenous testosterone on the expression of spermatid-specific proteins such as cAMP responsive element modulator, suggests that abnormal spermiogenesis may also be involved in SCI-induced sperm function impairments (12, 13). Huang et al. (12) have shown that altered responsiveness of Sertoli cell mRNA transcripts to exogenous buy testosterone powder, changes the endocrine and/or paracrine microenvironment within the seminiferous epithelium and tampers with proliferation and/or differentiation of spermatogenic cells in SCI. The beneficial effects of exogenous testosterone for sale demonstrate that spermatogenic effects of SCI are probably androgen-dependent (2, 12).
We observed no significant changes in free testosterone, DHEA, or SHBG in men with SCI, Table 3. No differences were observed among individuals with traumatic and non-traumatic injury, tetra- and paraplegia, users, and non-users of corticosteroids (Table 2). The association between age and time since injury and androgen hormones was non-linear in both men and women, and in men with motor complete traumatic SCI, these associations were described using restricted cubic splines. SHBG levels were 2558 pg/mL (IQR 2053–2777) and 2890 pg/mL (IQR 2020.5–3947) in men and women, respectively. Besides statistically significant differences in causes of TSCI and body weight, other personal and clinical characteristics did not differ between sexes. In Table 1, we present the most important clinical characteristics of study participants at admission to rehabilitation stratified by sex.
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